# A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Clinical Activity of CBX-663 in Participants With Relapsed or Refractory Myeloid Malignancies, Advanced Solid Tumors, or Recurrent or Progressive Glioblastoma.

Source: https://onco.cc/trials/nct07779798/  
OnCo record `nct07779798` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1 trial of CBX-663 run by Crossbow Therapeutics, Inc., now recruiting.

## Summary

A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Clinical Activity of CBX-663 in Participants With Relapsed or Refractory Myeloid Malignancies, Advanced Solid Tumors, or Recurrent or Progressive Glioblastoma. is a phase 1 interventional study registered as NCT07779798 by Crossbow Therapeutics, Inc., with 120 participants planned, started 2026-08-04. Conditions recorded: Advanced Solid Tumors, Recurrent or Progressive Glioblastoma and Relapse or Refractory Myeloid Malignancies. Interventions recorded: CBX-663.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Registry id: NCT07779798
- Phase: 1
- Setting: A Phase 1, Open-Label, Dose-Escalation Study to Evaluate Safety, Tolerability, and Clinical Activity of CBX-663 in Participants With Relapsed or Refractory Myeloid Malignancies, Advanced Solid Tumors, or Recurrent or Progressive Glioblastoma.
- Sponsor: Crossbow Therapeutics, Inc.
- Enrolled: 120

## Sources

- ClinicalTrials.gov NCT07779798: https://clinicaltrials.gov/study/NCT07779798

## Connected records

- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- drugs: [CBX-663](https://onco.cc/drugs/cbx-663/)
- companies: [Crossbow Therapeutics](https://onco.cc/companies/crossbow-therapeutics/)

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