# A Single-Arm, Phase II, Multicenter Clinical Study of Neoadjuvant Encorafenib Plus Cetuximab N01 and mFOLFOX6 in Patients With Locally Advanced BRAF V600E-Mutan

Source: https://onco.cc/trials/nct07789210/  
OnCo record `nct07789210` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Zhejiang University, now recruiting.

## Summary

A Single-Arm, Phase II, Multicenter Clinical Study of Neoadjuvant Encorafenib Plus Cetuximab N01 and mFOLFOX6 in Patients With Locally Advanced BRAF V600E-Mutant Colorectal Cancer With or Without Resectable Metastases is a phase 2, interventional study registered as NCT07789210 by Zhejiang University, with a registry enrolment figure of 25 participants, started 2026-06-30 and due to reach its primary completion in 2029-12-31. Interventions recorded: Neoadjuvant therapy of encorafenib plus cetuximab N01 and mFOLFOX6. Conditions listed: Colorectal Cancer; BRAF V600E Mutation Positive; Encorafenib; Cetuximab N01. Primary outcome: 18-month disease-free survival rate. Colorectal eligibility wording from the registry: "* Colorectal adenocarcinoma diagnosed by histopathology, preoperative staging: T4N0-2M0, T3N2M0, T0-4N0-2M1a (with metastatic lesions present, requiring MDT evaluation as resectable); PMMR/MSS, BRAF V600E mutation, and both NRAS and KRAS wild-type;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NEORAF
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07789210
- Phase: 2
- Setting: Neoadjuvant Encorafenib, Cetuximab N01 and mFolfox6 for BRAF V600E Mutated/ pMMR Localized Colorectal Cancer With or Without Resectable Metastases: a Single Arm, Multi-center, Phase 2 Clinical Trial
- Sponsor: Zhejiang University
- Enrolled: 25

## Sources

- ClinicalTrials.gov NCT07789210: https://clinicaltrials.gov/study/NCT07789210

## Connected records

- cancers: [BRAF V600E-mutant colorectal cancer](https://onco.cc/cancers/braf-v600e-colorectal/), [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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