# A Single-Arm, Phase II Study of Retlirafusp Alfa in Combination With XELOX and Bevacizumab for the First-Line Treatment of Advanced RAS-Mutated Colorectal Cance

Source: https://onco.cc/trials/nct07797244/  
OnCo record `nct07797244` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Dai, Guanghai, not yet recruiting.

## Summary

A Single-Arm, Phase II Study of Retlirafusp Alfa in Combination With XELOX and Bevacizumab for the First-Line Treatment of Advanced RAS-Mutated Colorectal Cancer With Liver Metastases (CRLM) is a phase 2, interventional study registered as NCT07797244 by Dai, Guanghai, with a registry enrolment figure of 46 participants, started 2026-10-29 and due to reach its primary completion in 2029-04. Interventions recorded: Retlirafusp alfa+XELOX+Bevacizumab Treatment. Conditions listed: Advanced RAS-Mutated Colorectal Cancer With Liver Metastases (CRLM). Primary outcome: Objective response rate (ORR). Colorectal eligibility wording from the registry: "Unresectable colorectal adenocarcinoma confirmed by histopathology or cytology;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07797244
- Phase: 2
- Setting: A Single-Arm, Phase II Study of Retlirafusp Alfa in Combination With XELOX and Bevacizumab for the First-Line Treatment of Advanced RAS-Mutated Colorectal Cancer With Liver Metastases (CRLM)
- Sponsor: Dai, Guanghai
- Enrolled: 46

## Sources

- ClinicalTrials.gov NCT07797244: https://clinicaltrials.gov/study/NCT07797244

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07797244.json