# A Study of DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC)

Source: https://onco.cc/trials/nct07807800/  
OnCo record `nct07807800` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in colorectal cancer, run by D. E. Shaw Research, LLC, not yet recruiting.

## Summary

A Study of DES-1357 in People With Deficient Mismatch Repair (dMMR)/Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC) is a phase 1/2, randomised interventional study registered as NCT07807800 by D. E. Shaw Research, LLC, with a registry enrolment figure of 88 participants, started 2026-12-03 and due to reach its primary completion in 2028-07-02. Interventions recorded: DES-1357. Conditions listed: Metastatic Colorectal Cancer (CRC). Primary outcome: Part 1: Number of Participants With Dose-Limiting Toxicities (DLTs); Part 2: Incidence and Severity of Treatment- related Treatment Emergent Adverse Events (TEAEs) Through at least 3 Cycles of DES-1357; Part 2: Best Overall Response (BOR). Colorectal eligibility wording from the registry: "Histologically or cytologically confirmed carcinoma of the colon and/or rectum deemed unresectable and/or with evidence of metastases, that has been cytologically or genetically confirmed as dMMR, and/or MSI-H". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07807800
- Phase: 1/2
- Setting: A Phase 1/2 Adaptive Study of DES-1357 in Participants With Deficient Mismatch Repair (dMMR) and/or Microsatellite Instability-High (MSI-H) Metastatic Colorectal Cancer (mCRC)
- Sponsor: D. E. Shaw Research, LLC
- Enrolled: 88

## Sources

- ClinicalTrials.gov NCT07807800: https://clinicaltrials.gov/study/NCT07807800

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07807800.json