# Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal Canc

Source: https://onco.cc/trials/nct07810114/  
OnCo record `nct07810114` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Fudan University, not yet recruiting.

## Summary

Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07810114 by Fudan University, with a registry enrolment figure of 52 participants, started 2026-08-28 and due to reach its primary completion in 2027-12-01. Interventions recorded: mFOLFOX6; Suvemcitug; Enlonstobart; Pelvic Chemoradiotherapy; Total Mesorectal Excision. Conditions listed: Rectal Cancer. Primary outcome: Pathologic Complete Response Rate. Colorectal eligibility wording from the registry: "Histologically confirmed rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: SPARE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07810114
- Phase: 2
- Setting: A Phase II Study of Total Neoadjuvant mFOLFOX6 Plus Suvemcitug and Enlonstobart With Selective Omission of Pelvic Radiotherapy for High-Risk Mid-Rectal Locally Advanced Rectal Cancer With MSS Status
- Sponsor: Fudan University
- Enrolled: 52

## Sources

- ClinicalTrials.gov NCT07810114: https://clinicaltrials.gov/study/NCT07810114

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07810114.json