# A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Source: https://onco.cc/trials/nct07816380/  
OnCo record `nct07816380` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Guangzhou JOYO Pharma Co., Ltd, not yet recruiting.

## Summary

A Phase III Study to Evaluate the Efficacy and Safety of JYP0322 in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT07816380 by Guangzhou JOYO Pharma Co., Ltd, with a registry enrolment figure of 216 participants, started 2026-10-30 and due to reach its primary completion in 2028-12-30. Interventions recorded: JYP0322 Tablets; Crizotinib Capsules. Conditions listed: NSCLC (Advanced Non-small Cell Lung Cancer). Primary outcome: Progression-Free Survival (PFS) assessed by Blinded Independent Central Review (BICR/BIRC) per RECIST v1.1. Lung eligibility wording from the registry: "Histologically or cytologically confirmed, unresectable locally advanced (AJCC 9th edition stage IIIB or IIIC not amenable to multimodality therapy) or metastatic (stage IV) ROS1-positive non-small cell lung cancer (NSCLC)". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT07816380
- Phase: 3
- Setting: A Randomized, Open-Label, Multicenter, Phase III Study to Evaluate the Efficacy and Safety of JYP0322 Versus Crizotinib in Previously Untreated ROS1-Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Sponsor: Guangzhou JOYO Pharma Co., Ltd
- Enrolled: 216

## Sources

- ClinicalTrials.gov NCT07816380: https://clinicaltrials.gov/study/NCT07816380

## Connected records

- cancers: [ROS1-positive non-small-cell lung cancer](https://onco.cc/cancers/ros1-positive-nsclc/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct07816380.json