# mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct07817888/  
OnCo record `nct07817888` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of FOLFOXIRI in colorectal cancer, run by Sixth Affiliated Hospital, Sun Yat-sen University, not yet recruiting.

## Summary

mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT07817888 by Sixth Affiliated Hospital, Sun Yat-sen University, with a registry enrolment figure of 119 participants, started 2026-09-30 and due to reach its primary completion in 2028-09-30. Interventions recorded: FOLFOXIRI + Bevacizumab. Conditions listed: Phase 2 Study. Primary outcome: 3-year Disease Free Survival. Colorectal eligibility wording from the registry: "* Histologically confirmed rectal adenocarcinoma;". No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: FOBEAR-ii
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT07817888
- Phase: 2
- Setting: Neoadjuvant mFOLFOXIRI Plus Bevacizumab for Organ Preservation in Locally Advanced Rectal Cancer: A Singe-arm Phase II Study
- Sponsor: Sixth Affiliated Hospital, Sun Yat-sen University
- Enrolled: 119

## Sources

- ClinicalTrials.gov NCT07817888: https://clinicaltrials.gov/study/NCT07817888

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)](https://onco.cc/drugs/folfoxiri/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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