# Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic Adenocarcinoma

Source: https://onco.cc/trials/nct07824960/  
OnCo record `nct07824960` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of avutometinib + defactinib in pancreatic cancer, run by University of Virginia, not yet recruiting.

## Summary

Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic Adenocarcinoma is a phase 1/2, interventional study registered as NCT07824960 by University of Virginia, with a registry enrolment figure of 31 participants, started 2026-10-01 and due to reach its primary completion in 2029-04. Interventions recorded: Avutometinib (VS-6766) + Defactinib (VS-6063). Conditions listed: Pancreatic Cancer; PDAC - Pancreatic Ductal Adenocarcinoma; Metastatic Pancreatic Carcinoma; Locally Advanced Pancreatic Cancer. Primary outcome: Dose limiting toxicities (DLTs) - Part A; Objective response (OR) - Part B. Pancreatic eligibility wording from the registry: "Adenocarcinoma of the pancreas, confirmed by histology or cytology". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: Panc 004
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT07824960
- Phase: 1/2
- Setting: Neoadjuvant Avutometinib/Defactinib and mFOLFIRINOX Combination Therapy in Pancreatic Adenocarcinoma: A Phase IB/II Safety and Efficacy Study
- Sponsor: University of Virginia
- Enrolled: 31

## Sources

- ClinicalTrials.gov NCT07824960: https://clinicaltrials.gov/study/NCT07824960

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/), [Metastatic pancreatic ductal adenocarcinoma](https://onco.cc/cancers/metastatic-pdac/), [Resectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/resectable-pdac/)
- drugs: [Avutometinib + defactinib](https://onco.cc/drugs/avutometinib-defactinib/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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