# Cryoablation Combined With QL1706 (Iparomlimab/Tuvonralimab) Plus Lenvatinib in Patients With Advanced Biliary Tract Cancer.

Source: https://onco.cc/trials/nct07829874/  
OnCo record `nct07829874` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of lenvatinib in gallbladder cancer and other biliary tract cancers, run by Fudan University, not yet recruiting.

## Summary

Cryoablation Combined With QL1706 (Iparomlimab/Tuvonralimab) Plus Lenvatinib in Patients With Advanced Biliary Tract Cancer. is a phase 2, randomised interventional study registered as NCT07829874 by Fudan University, with a registry enrolment figure of 180 participants, started 2026-09-20 and due to reach its primary completion in 2028-09-20. Interventions recorded: QL1706 (Iparomlimab/Tuvonralimab), Lenvatinib, Cryoablation. Conditions listed: Biliary Tract Cancer (BTC). Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: planned
- Last checked: 2026-09-24
- Also known as: CASTLE-ZS-04
- Tags: ctgov-ingest; gallbladder-deep-dive
- Registry id: NCT07829874
- Phase: 2
- Setting: QL1706 (Iparomlimab/Tuvonralimab) Plus Lenvatinib With or Without Cryoablation for Advanced Biliary Tract Cancer (CASTLE-ZS-04): a Multicenter, Randomized, Phase 2 Study
- Sponsor: Fudan University
- Enrolled: 180

## Sources

- ClinicalTrials.gov NCT07829874: https://clinicaltrials.gov/study/NCT07829874

## Connected records

- cancers: [Biliary tract cancer (all types)](https://onco.cc/cancers/biliary-tract-cancer/), [Biliary tract cancer (cholangiocarcinoma)](https://onco.cc/cancers/cholangiocarcinoma/), [Gallbladder cancer](https://onco.cc/cancers/gallbladder/)
- technologies: [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/)
- drugs: [Lenvatinib](https://onco.cc/drugs/lenvatinib/)
- terms: [Gallbladder cancer in biliary tract cancer trials (eligibility and subgroups)](https://onco.cc/terms/gallbladder-cancer-in-biliary-trials/)

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