# NDRG1

Source: https://onco.cc/targets/ndrg1/  
OnCo record `ndrg1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NDRG1 (N-myc downstream regulated 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Lung cancer, Colorectal cancer and 1 more.

## Summary

Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumour suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis.

Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.99, animal model 0.44, genetic association 0.00, somatic mutation 0.98).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: N-myc downstream regulated 1; DRG1; TDD5; NDR1; CAP43
- Tags: cancer-genes-wave
- Symbol: NDRG1
- Class: other
- Biology: Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumour suppressor in many cell types. Necessary but not sufficient for p53/TP53-mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Location: Cytoplasm, cytosol; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Nucleus; Cell membrane (UniProt). Locus 8q24.22 (HGNC).
- Where found: Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254); Lung cancer: Open Targets association 0.53 with lung cancer (MONDO_0008903); Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575); Gastric & gastro-oesophageal junction cancer: Open Targets association 0.51 with gastric cancer (MONDO_0001056)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7679: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7679
- UniProt Q92597: https://www.uniprot.org/uniprotkb/Q92597/entry
- NCBI Gene 10397: https://www.ncbi.nlm.nih.gov/gene/10397
- Ensembl ENSG00000104419: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000104419

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/), [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/), [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)

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JSON: https://onco.cc/api/v1/entities/ndrg1.json