# CD112 (nectin-2)

Source: https://onco.cc/targets/nectin2/  
OnCo record `nectin2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CD112 is a widespread cell-adhesion molecule that can either encourage a T cell (through CD226) or hold it back (through PVRIG and TIGIT), depending on which receptor grabs it first.

## Summary

NECTIN2 (chromosome 19q13.32) is a modulator of T-cell signalling that acts as a costimulator or a coinhibitor depending on the receptor it binds: through CD226 it stimulates proliferation and the production of IL-2, IL-5, IL-10, IL-13 and interferon gamma, through PVRIG it inhibits proliferation, and the two interactions are competitive; it is ubiquitously expressed and a probable cell-adhesion protein (UniProt Q92692). TIGIT binds PVR (CD155) or NECTIN2 (CD112) on antigen-presenting cells and sends inhibitory signals to the T cell or NK cell (UniProt Q495A1).

## Fields

- Kind: Target
- Last checked: 2026-09-24
- Also known as: CD112; PVRL2; nectin-2; PRR2; HVEB
- Tags: checkpoint-map
- Symbol: NECTIN2
- Class: checkpoint
- Biology: The second ligand of the TIGIT axis and the sole established ligand of PVRIG.
- Where found: Ubiquitous (UniProt Q92692)

## Notes

- Prevalence not recorded: HGNC and UniProt carry no positivity rates.

## Sources

- HGNC HGNC:9707: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9707
- UniProt Q92692: https://www.uniprot.org/uniprotkb/Q92692/entry
- NCBI Gene 5819: https://www.ncbi.nlm.nih.gov/gene/5819

## Connected records

- targets: [CD155 (PVR)](https://onco.cc/targets/pvr/), [PVRIG (CD112R)](https://onco.cc/targets/pvrig/), [TIGIT](https://onco.cc/targets/tigit/)
- technologies: [TIGIT blockade](https://onco.cc/technologies/tigit-blockade/)
- pathways: [The cancer-immunity cycle](https://onco.cc/pathways/cancer-immunity-cycle/)
- terms: [Checkpoint (two meanings)](https://onco.cc/terms/checkpoint/)

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JSON: https://onco.cc/api/v1/entities/nectin2.json