# NEDD9

Source: https://onco.cc/targets/nedd9/  
OnCo record `nedd9` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NEDD9 (Enhancer of filamentation 1) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Hepatocellular carcinoma.

## Summary

Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: neural precursor cell expressed, developmentally down-regulated 9; Enhancer of filamentation 1; HEF1; CAS-L; CASS2
- Tags: cancer-genes-wave
- Symbol: NEDD9
- Class: other
- Biology: Scaffolding protein which plays a central coordinating role for tyrosine-kinase-based signalling related to cell adhesion. As a focal adhesion protein, plays a role in embryonic fibroblast migration. May play an important role in integrin beta-1 or B cell antigen receptor (BCR) mediated signalling in B- and T-cells. Integrin beta-1 stimulation leads to recruitment of various proteins including CRKL and SHPTP2 to the tyrosine phosphorylated form. Promotes adhesion and migration of lymphocytes; as a result required for the correct migration of lymphocytes to the spleen and other secondary lymphoid organs. Plays a role in the organisation of T-cell F-actin cortical cytoskeleton and the centralisation of T-cell receptor microclusters at the immunological synapse. Location: Cytoplasm, cell cortex; Nucleus; Golgi apparatus; Cell projection, lamellipodium (UniProt). Locus 6p24.2 (HGNC).
- Where found: Hepatocellular carcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7733: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7733
- UniProt Q14511: https://www.uniprot.org/uniprotkb/Q14511/entry
- NCBI Gene 4739: https://www.ncbi.nlm.nih.gov/gene/4739
- Ensembl ENSG00000111859: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111859

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Hepatocellular carcinoma](https://onco.cc/cancers/hcc/)

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JSON: https://onco.cc/api/v1/entities/nedd9.json