# NEIL1

Source: https://onco.cc/targets/neil1/  
OnCo record `neil1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NEIL1 (Endonuclease 8-like 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.

## Summary

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognises and removes damaged bases. Has a preference for oxidised pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil.

Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.89, animal model 0.39, genetic association 0.08).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nei like DNA glycosylase 1; Endonuclease 8-like 1; FLJ22402; hFPG1; NEI1; FPG1
- Tags: cancer-genes-wave
- Symbol: NEIL1
- Class: enzyme
- Biology: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognises and removes damaged bases. Has a preference for oxidised pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Nucleus; Chromosome (UniProt). Locus 15q24.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18448: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18448
- UniProt Q96FI4: https://www.uniprot.org/uniprotkb/Q96FI4/entry
- NCBI Gene 79661: https://www.ncbi.nlm.nih.gov/gene/79661
- Ensembl ENSG00000140398: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000140398

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/neil1.json