# NEK10

Source: https://onco.cc/targets/nek10/  
OnCo record `nek10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NEK10 (Serine/threonine-protein kinase Nek10) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signalling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport.

Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.37, genetic association 0.67).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: NIMA related kinase 10; Serine/threonine-protein kinase Nek10; FLJ32685
- Tags: cancer-genes-wave
- Symbol: NEK10
- Class: kinase
- Biology: Plays a role in the cellular response to UV irradiation. Mediates G2/M cell cycle arrest, MEK autoactivation and ERK1/2-signalling pathway activation in response to UV irradiation. In ciliated cells of airways, it is involved in the regulation of mucociliary transport. Locus 3p24.1 (HGNC).
- Where found: Breast cancer: Open Targets association 0.51 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:18592: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18592
- UniProt Q6ZWH5: https://www.uniprot.org/uniprotkb/Q6ZWH5/entry
- NCBI Gene 152110: https://www.ncbi.nlm.nih.gov/gene/152110
- Ensembl ENSG00000163491: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000163491

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/nek10.json