# N17350

Source: https://onco.cc/drugs/neu-001/  
OnCo record `neu-001` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

N17350 is an experimental enzyme therapy: elastase injected into the tumour from Onchilles Pharma, in phase 1 trials for advanced solid tumours, triple-negative breast cancer and cutaneous squamous cell carcinoma and other cancers.

## Summary

N17350 (NEU-001) is an enzyme therapy: elastase injected into the tumour from Onchilles Pharma. A tumour-directed therapeutic elastase designed to kill cancer cells selectively while preserving immune cells, causing immunogenic cancer cell death that stimulates anti-tumour immunity; the company says it works through the ELANE pathway, which targets altered histone H1 biology. Its furthest stage is phase 1, for advanced solid tumours, triple-negative breast cancer, cutaneous squamous cell carcinoma and melanoma. ClinicalTrials.gov registers it in one study linked below. OP-NEU-101 phase 1/2 (NCT07339176, registry PHASE1/PHASE2, recruiting) enrolling in the US and Australia; first patient dosed announced 4 June 2026. Whether it works in people has not been established unless a trial below reports it.

## Fields

- Kind: Treatment
- Status: phase-1
- Last checked: 2026-11-03
- Also known as: NEU-001
- Tags: pipeline; ctgov-ingest
- Code: NEU-001
- Modality: Enzyme therapy: elastase injected into the tumour
- Mechanism: A tumour-directed therapeutic elastase designed to kill cancer cells selectively while preserving immune cells, causing immunogenic cancer cell death that stimulates anti-tumour immunity; the company says it works through the ELANE pathway, which targets altered histone H1 biology.

## Sources

- Onchilles Pharma: onchillespharma.com: https://www.onchillespharma.com/
- Onchilles Pharma: onchillespharma.com: https://www.onchillespharma.com/
- Onchilles Pharma: onchillespharma.com: https://www.onchillespharma.com/
- Onchilles Pharma: clinicaltrials.gov: https://clinicaltrials.gov/api/v2/studies/NCT07339176
- ClinicalTrials.gov: trials of NEU-001: https://clinicaltrials.gov/search?intr=NEU-001

## Connected records

- cancers: [Cutaneous squamous cell carcinoma](https://onco.cc/cancers/cutaneous-scc/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Melanoma](https://onco.cc/cancers/melanoma/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- companies: [Onchilles Pharma](https://onco.cc/companies/onchilles-pharma/)
- trials: [Intratumoral N17350 in Advanced Solid Tumors](https://onco.cc/trials/nct07339176/)

---
JSON: https://onco.cc/api/v1/entities/neu-001.json