# NKTR

Source: https://onco.cc/targets/nktr/  
OnCo record `nktr` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NKTR (NK-tumour recognition protein) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.

## Summary

PPIase that catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumour-recognition complex involved in the function of NK cells.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: natural killer cell triggering receptor; NK-tumor recognition protein; p104; CypNK
- Tags: cancer-genes-wave
- Symbol: NKTR
- Class: oncogene
- Biology: PPIase that catalyses the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Component of a putative tumour-recognition complex involved in the function of NK cells. Location: Cell membrane (UniProt). Locus 3p22.1 (HGNC).
- Where found: Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7833: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7833
- UniProt P30414: https://www.uniprot.org/uniprotkb/P30414/entry
- NCBI Gene 4820: https://www.ncbi.nlm.nih.gov/gene/4820
- Ensembl ENSG00000114857: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114857

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)
- trials: [A Study of Bempegaldesleukin (NKTR-214: BEMPEG) in Combination With Nivolumab Compared With the Investigator's Choice of a Tyrosine Kinase Inhibitor (TKI) Therapy (Either Sunitinib or Cabozantinib Monotherapy) for Advanced Metastatic Renal Cell Carcinoma (RCC)](https://onco.cc/trials/nct03729245/), [A Study of NKTR-214 Combined With Nivolumab vs Nivolumab Alone in Participants With Previously Untreated Inoperable or Metastatic Melanoma](https://onco.cc/trials/nct03635983/)

---
JSON: https://onco.cc/api/v1/entities/nktr.json