# NKX3-1

Source: https://onco.cc/targets/nkx3-1/  
OnCo record `nkx3-1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NKX3-1 (Homeobox protein Nkx-3.1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.

## Summary

Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumour suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells.

Open Targets scores its association with cancer at 0.50 (direct and indirect evidence; datatypes literature 0.96, animal model 0.88, genetic association 0.61).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: NK3 homeobox 1; Homeobox protein Nkx-3.1; NKX3.1; BAPX2; NKX3A
- Tags: cancer-genes-wave
- Symbol: NKX3-1
- Class: transcription
- Biology: Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumour suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).
- Where found: Prostate cancer: Open Targets association 0.50 with prostate cancer (MONDO_0008315)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7838: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7838
- UniProt Q99801: https://www.uniprot.org/uniprotkb/Q99801/entry
- NCBI Gene 4824: https://www.ncbi.nlm.nih.gov/gene/4824
- Ensembl ENSG00000167034: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167034

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Prostate cancer](https://onco.cc/cancers/prostate/)
- pathways: [Prostate cancer (KEGG map)](https://onco.cc/pathways/prostate-cancer-signalling/)

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JSON: https://onco.cc/api/v1/entities/nkx3-1.json