# NMS-03305293

Source: https://onco.cc/drugs/nms-03305293/  
OnCo record `nms-03305293` (Treatment). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NMS-03305293 is an experimental pill being studied to block a DNA-repair enzyme in cancer cells.

## Summary

PARP1-selective, brain-penetrant inhibitor, also called NMS-293. The linked registry records distinguish recruiting, closed, and discontinued studies; those states do not establish comparative efficacy or approval. The monotherapy study NCT04182516 stopped after 52 actual participants because the sponsor shifted towards combinations, explicitly not because of emerging safety or efficacy concerns. Combination studies include temozolomide and topotecan.

## Fields

- Kind: Treatment
- Status: phase-2
- Last checked: 2026-10-06
- Also known as: NMS-293
- Modality: Small-molecule PARP1 inhibitor
- Mechanism: PARP1-selective, brain-penetrant inhibitor, also called NMS-293.

## Sources

- ClinicalTrials.gov NCT06931626: https://clinicaltrials.gov/study/NCT06931626
- ClinicalTrials.gov NCT04910022: https://clinicaltrials.gov/study/NCT04910022
- ClinicalTrials.gov NCT06930755: https://clinicaltrials.gov/study/NCT06930755
- ClinicalTrials.gov NCT04182516: https://clinicaltrials.gov/study/NCT04182516
- Primary publication or sponsor source: https://doi.org/10.1158/1535-7163.targ-23-lb_a12

## Connected records

- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- targets: [PARP](https://onco.cc/targets/parp/)
- trials: [Ph I/II Study of NMS-03305293+TMZ in Adult Patients With Recurrent Glioblastoma](https://onco.cc/trials/nct04910022/), [Study of NMS-03305293 in Adult Patient With Relapsed Small Cell Lung Cancer](https://onco.cc/trials/nct06931626/), [Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer](https://onco.cc/trials/nct06930755/), [Study of NMS-03305293 in Pts with Selected Advanced/Metastatic Solid Tumors](https://onco.cc/trials/nct04182516/)

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