# Noopur Raje

Source: https://onco.cc/people/noopur-raje/  
OnCo record `noopur-raje` (Person). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Led the first-in-human trial of BCMA CAR-T (bb2121) in myeloma and studies of bone disease treatment.

## Summary

Noopur Raje led the first-in-human trial of bb2121 (idecabtagene vicleucel), which showed deep responses in heavily pretreated myeloma and launched BCMA-directed CAR-T therapy, and the trial establishing denosumab as an alternative to zoledronic acid for myeloma bone disease. She directs the myeloma centre at MGH and leads trials of bispecifics and next-generation cell therapies.

## Fields

- Kind: Person
- Last checked: 2026-09-10
- Tags: myeloma; car-t; bone-disease
- Role: Director, Center for Multiple Myeloma, Massachusetts General Hospital Cancer Center
- Specialisms: Multiple myeloma; CAR T-cell therapy; Bone disease; Novel agents

## Sources

- PubMed: https://pubmed.ncbi.nlm.nih.gov/?term=Raje%20N%5BAuthor%5D%20myeloma%20BCMA

## Connected records

- cancers: [Multiple myeloma](https://onco.cc/cancers/multiple-myeloma/)
- technologies: [CAR-T cell therapy](https://onco.cc/technologies/car-t/)
- targets: [BCMA](https://onco.cc/targets/bcma/)
- institutions: [Massachusetts General Hospital Cancer Center](https://onco.cc/institutions/mgh/)
- key papers: [KarMMa-3: ide-cel CAR-T versus standard regimens in triple-class-exposed relapsed myeloma](https://onco.cc/key-papers/paper-karmma-3-ide-cel-nejm-2023/)

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