# NOX4

Source: https://onco.cc/targets/nox4/  
OnCo record `nox4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NOX4 (NADPH oxidase 4) is an enzyme. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity.

Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.76, genetic association 0.42, clinical 0.12).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: NADPH oxidase 4; KOX-1
- Tags: cancer-genes-wave
- Symbol: NOX4
- Class: enzyme
- Biology: NADPH oxidase that catalyses predominantly the reduction of oxygen to H2O2. Can also catalyse to a smaller extent, the reduction of oxygen to superoxide. May function as an oxygen sensor regulating the KCNK3/TASK-1 potassium channel and HIF1A activity. May regulate insulin signalling cascade. May play a role in apoptosis, bone resorption and lipolysaccharide-mediated activation of NFKB. May produce superoxide in the nucleus and play a role in regulating gene expression upon cell stimulation. Location: Cytoplasm; Endoplasmic reticulum membrane; Cell membrane; Cell junction, focal adhesion (UniProt). Locus 11q14.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: Open Targets known-drug datatype score 0.12. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7891: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7891
- UniProt Q9NPH5: https://www.uniprot.org/uniprotkb/Q9NPH5/entry
- NCBI Gene 50507: https://www.ncbi.nlm.nih.gov/gene/50507
- Ensembl ENSG00000086991: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000086991

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/nox4.json