# NPTXR

Source: https://onco.cc/targets/nptxr/  
OnCo record `nptxr` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NPTXR (Neuronal pentraxin receptor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Gastric & gastro-oesophageal junction cancer.

## Summary

May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin and Fluorouracil.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: neuronal pentraxin receptor; Neuronal pentraxin receptor
- Tags: cancer-genes-wave
- Symbol: NPTXR
- Class: other
- Biology: May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses. Location: Membrane (UniProt). Locus 22q13.1 (HGNC).
- Where found: Gastric & gastro-oesophageal junction cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7954: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7954
- UniProt O95502: https://www.uniprot.org/uniprotkb/O95502/entry
- NCBI Gene 23467: https://www.ncbi.nlm.nih.gov/gene/23467
- Ensembl ENSG00000221890: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000221890

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)

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JSON: https://onco.cc/api/v1/entities/nptxr.json