# NR2F2

Source: https://onco.cc/targets/nr2f2/  
OnCo record `nr2f2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NR2F2 (COUP transcription factor 2) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.

## Summary

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear receptor subfamily 2 group F member 2; COUP transcription factor 2; COUP-TFII; COUPTFB; SVP40; NF-E3; COUPTF2; ARP1; TFCOUP2
- Tags: cancer-genes-wave
- Symbol: NR2F2
- Class: transcription
- Biology: Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A. May be required to establish ovary identity during early gonad development. Location: Nucleus (UniProt). Locus 15q26.2 (HGNC).
- Where found: Colorectal cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7976: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7976
- UniProt P24468: https://www.uniprot.org/uniprotkb/P24468/entry
- NCBI Gene 7026: https://www.ncbi.nlm.nih.gov/gene/7026
- Ensembl ENSG00000185551: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185551

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/nr2f2.json