# NR4A2

Source: https://onco.cc/targets/nr4a2/  
OnCo record `nr4a2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NR4A2 (Nuclear receptor subfamily 4 group A member 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.

## Summary

Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons.

CIViC holds 3 clinical evidence items and 0 assertions across 1 variant, naming Gemcitabine and C-DIM 12.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear receptor subfamily 4 group A member 2; Nuclear receptor subfamily 4 group A member 2; TINUR; RNR1; HZF-3; NURR1
- Tags: cancer-genes-wave
- Symbol: NR4A2
- Class: transcription
- Biology: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Location: Cytoplasm; Nucleus (UniProt). Locus 2q24.1 (HGNC).
- Where found: Pancreatic ductal adenocarcinoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 2 therapies; CIViC holds 3 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7981: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7981
- UniProt P43354: https://www.uniprot.org/uniprotkb/P43354/entry
- NCBI Gene 4929: https://www.ncbi.nlm.nih.gov/gene/4929
- Ensembl ENSG00000153234: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000153234

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)

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JSON: https://onco.cc/api/v1/entities/nr4a2.json