# NRG2

Source: https://onco.cc/targets/nrg2/  
OnCo record `nrg2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NRG2 (Pro-neuregulin-2, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerisation with the EGF receptor.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.95, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: neuregulin 2; Pro-neuregulin-2, membrane-bound isoform; Don-1; HRG2
- Tags: cancer-genes-wave
- Symbol: NRG2
- Class: other
- Biology: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. May also promote the heterodimerisation with the EGF receptor. Location: Cell membrane; Secreted (UniProt). Locus 5q31.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7998: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7998
- UniProt O14511: https://www.uniprot.org/uniprotkb/O14511/entry
- NCBI Gene 9542: https://www.ncbi.nlm.nih.gov/gene/9542
- Ensembl ENSG00000158458: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000158458

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/nrg2.json