# NRG3

Source: https://onco.cc/targets/nrg3/  
OnCo record `nrg3` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NRG3 (Pro-neuregulin-3, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors.

Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.70, affected pathway 0.95, genetic association 0.53).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: neuregulin 3; Pro-neuregulin-3, membrane-bound isoform
- Tags: cancer-genes-wave
- Symbol: NRG3
- Class: other
- Biology: Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes. Location: Cell membrane; Secreted (UniProt). Locus 10q23.1 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:7999: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:7999
- UniProt P56975: https://www.uniprot.org/uniprotkb/P56975/entry
- NCBI Gene 10718: https://www.ncbi.nlm.nih.gov/gene/10718
- Ensembl ENSG00000185737: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185737

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/nrg3.json