# NRG4

Source: https://onco.cc/targets/nrg4/  
OnCo record `nrg4` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NRG4 (Pro-neuregulin-4, membrane-bound isoform) is a gene. In the public catalogues the evidence so far is association rather than a proven role.

## Summary

Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors.

Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.95, genetic association 0.00).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: neuregulin 4; Pro-neuregulin-4, membrane-bound isoform; HRG4
- Tags: cancer-genes-wave
- Symbol: NRG4
- Class: other
- Biology: Low affinity ligand for the ERBB4 tyrosine kinase receptor. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. Does not bind to the ERBB1, ERBB2 and ERBB3 receptors. Location: Cell membrane; Secreted (UniProt). Locus 15q24.2 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29862: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29862
- UniProt Q8WWG1: https://www.uniprot.org/uniprotkb/Q8WWG1/entry
- NCBI Gene 145957: https://www.ncbi.nlm.nih.gov/gene/145957
- Ensembl ENSG00000169752: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000169752

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/nrg4.json