# NRIP1

Source: https://onco.cc/targets/nrip1/  
OnCo record `nrip1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NRIP1 (Nuclear receptor-interacting protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer.

## Summary

Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC.

Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.65).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear receptor interacting protein 1; Nuclear receptor-interacting protein 1; RIP140
- Tags: cancer-genes-wave
- Symbol: NRIP1
- Class: transcription
- Biology: Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. Location: Nucleus (UniProt). Locus 21q11.2-q21.1 (HGNC).
- Where found: Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8001: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8001
- UniProt P48552: https://www.uniprot.org/uniprotkb/P48552/entry
- NCBI Gene 8204: https://www.ncbi.nlm.nih.gov/gene/8204
- Ensembl ENSG00000180530: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000180530

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)

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JSON: https://onco.cc/api/v1/entities/nrip1.json