# NRK

Source: https://onco.cc/targets/nrk/  
OnCo record `nrk` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NRK (Nik-related protein kinase) is a protein kinase, an enzyme that switches other proteins on by adding phosphate groups. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Non-small-cell lung cancer.

## Summary

May phosphorylate cofilin-1 and induce actin polymerisation through this process, during the late stages of embryogenesis. Involved in the TNF-induced signalling pathway.

IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Lung Squamous Cell Carcinoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: Nik related kinase; Nik-related protein kinase; DKFZp686A17109
- Tags: cancer-genes-wave
- Symbol: NRK
- Class: kinase
- Biology: May phosphorylate cofilin-1 and induce actin polymerisation through this process, during the late stages of embryogenesis. Involved in the TNF-induced signalling pathway. Locus Xq22.3 (HGNC).
- Where found: Non-small-cell lung cancer: IntOGen driver in 1 cohort (LUSC)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:25391: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25391
- UniProt Q7Z2Y5: https://www.uniprot.org/uniprotkb/Q7Z2Y5/entry
- NCBI Gene 203447: https://www.ncbi.nlm.nih.gov/gene/203447
- Ensembl ENSG00000123572: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000123572

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)

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JSON: https://onco.cc/api/v1/entities/nrk.json