# A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)

Source: https://onco.cc/trials/nsclc-4/  
OnCo record `nsclc-4` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial testing PF-08046054 in non-small-cell lung cancer, now recruiting.

## Summary

A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC) is a phase 3 interventional study registered as NCT07144280, led by Pfizer, and recruiting on the registry. Official title: PADL1NK-005: A Randomised, Phase 3, Open-Label Study to Evaluate PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC). Planned enrolment is 680 participants (estimated). The study started in 2025-09-29 and primary completion is expected in 2028-03-10. No results have been posted on ClinicalTrials.gov.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-11
- Also known as: PADL1NK-005
- Tags: ctgov-ingest
- Registry id: NCT07144280
- Phase: 3
- Setting: PADL1NK-005: A Randomized, Phase 3, Open-Label Study to Evaluate PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
- Sponsor: Pfizer
- Enrolled: 680

## Sources

- ClinicalTrials.gov NCT07144280: https://clinicaltrials.gov/study/NCT07144280

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- drugs: [PF-08046054](https://onco.cc/drugs/pf-08046054/)
- companies: [Pfizer (incl. Seagen)](https://onco.cc/companies/pfizer/)

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JSON: https://onco.cc/api/v1/entities/nsclc-4.json