# NT5C3A

Source: https://onco.cc/targets/nt5c3a/  
OnCo record `nt5c3a` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NT5C3A (Cytosolic 5'-nucleotidase 3A) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.

## Summary

Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: 5'-nucleotidase, cytosolic IIIA; Cytosolic 5'-nucleotidase 3A; UMPH1; PSN1; PN-I; P5'N-1; cN-III; p36; hUMP1; NT5C3
- Tags: cancer-genes-wave
- Symbol: NT5C3A
- Class: oncogene
- Biology: Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. Location: Cytoplasm; Endoplasmic reticulum (UniProt). Locus 7p14.3 (HGNC).
- Where found: Acute myeloid leukaemia: IntOGen driver in 1 cohort (AML)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:17820: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17820
- UniProt Q9H0P0: https://www.uniprot.org/uniprotkb/Q9H0P0/entry
- NCBI Gene 51251: https://www.ncbi.nlm.nih.gov/gene/51251
- Ensembl ENSG00000122643: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000122643

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/)

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JSON: https://onco.cc/api/v1/entities/nt5c3a.json