# NTHL1

Source: https://onco.cc/targets/nthl1/  
OnCo record `nthl1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NTHL1 (Endonuclease III-like protein 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Colorectal cancer.

## Summary

Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination.

Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.76, affected pathway 0.91, literature 0.93, genetic association 0.61, somatic mutation 0.49, animal model 0.47).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nth like DNA glycosylase 1; Endonuclease III-like protein 1; NTH1; OCTS3
- Tags: cancer-genes-wave
- Symbol: NTHL1
- Class: enzyme
- Biology: Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyses the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognises and repairs oxidative base damage of pyrimidines. Also has 8-oxo-7,8-dihydroguanine (8-oxoG) DNA glycosylase activity. Acts preferentially on DNA damage opposite guanine residues in DNA. Location: Nucleus; Mitochondrion (UniProt). Locus 16p13.3 (HGNC).
- Where found: Colorectal cancer: Open Targets association 0.58 with colorectal cancer (MONDO_0005575)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8028: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8028
- UniProt P78549: https://www.uniprot.org/uniprotkb/P78549/entry
- NCBI Gene 4913: https://www.ncbi.nlm.nih.gov/gene/4913
- Ensembl ENSG00000065057: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000065057

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)

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JSON: https://onco.cc/api/v1/entities/nthl1.json