# NUTM1

Source: https://onco.cc/targets/nutm1/  
OnCo record `nutm1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NUTM1 (NUT family member 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a fusion partner, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Skin cancer, Oesophageal cancer, Ovarian cancer and 4 more.

## Summary

Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes literature 0.84, affected pathway 0.61, genetic association 0.00, somatic mutation 0.83). IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Oesophageal Adenocarcinoma, Ovarian Epithelial Tumour.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: NUT midline carcinoma family member 1; NUT family member 1; DKFZp434O192; FAM22H; C15orf55
- Tags: cancer-genes-wave
- Symbol: NUTM1
- Class: tumor-suppressor
- Biology: Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Location: Cytoplasm; Nucleus (UniProt). Locus 15q14 (HGNC).
- Where found: Skin cancer: Open Targets association 0.59 with skin cancer (MONDO_0002898); Oesophageal cancer: IntOGen driver in 1 cohort (ESCA); Ovarian cancer: IntOGen driver in 1 cohort (OVT); Lung cancer: Open Targets association 0.56 with lung cancer (MONDO_0008903); Oesophageal and junctional adenocarcinoma: IntOGen driver in 1 cohort (ESCA); Melanoma: Open Targets association 0.56 with melanoma (MONDO_0005105)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:29919: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29919
- UniProt Q86Y26: https://www.uniprot.org/uniprotkb/Q86Y26/entry
- NCBI Gene 256646: https://www.ncbi.nlm.nih.gov/gene/256646
- Ensembl ENSG00000184507: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000184507

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/), [Open Targets Platform](https://onco.cc/collections/open-targets/)
- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/), [Melanoma](https://onco.cc/cancers/melanoma/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Oesophageal and junctional adenocarcinoma](https://onco.cc/cancers/oesophageal-adenocarcinoma/), [Oesophageal cancer](https://onco.cc/cancers/esophageal/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Skin cancer (all types)](https://onco.cc/cancers/skin-cancer/)

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JSON: https://onco.cc/api/v1/entities/nutm1.json