# NVL

Source: https://onco.cc/targets/nvl/  
OnCo record `nvl` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NVL (Nuclear valosin-containing protein-like) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Glioma & glioblastoma.

## Summary

Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus.

IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Glioblastoma Multiforme.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear VCP like; Nuclear valosin-containing protein-like; NVL2
- Tags: cancer-genes-wave
- Symbol: NVL
- Class: oncogene
- Biology: Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyses the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity. Location: Nucleus, nucleoplasm; Nucleus, nucleolus (UniProt). Locus 1q42.11 (HGNC).
- Where found: Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it an activating (Act) driver in 1 cohort. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8070: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8070
- UniProt O15381: https://www.uniprot.org/uniprotkb/O15381/entry
- NCBI Gene 4931: https://www.ncbi.nlm.nih.gov/gene/4931
- Ensembl ENSG00000143748: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000143748

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Glioma & glioblastoma](https://onco.cc/cancers/glioblastoma/)
- trials: [A Study of Zidesamtinib (NVL-520) in Patients With Advanced NSCLC and Other Solid Tumors Harboring ROS1 Rearrangement (ARROS-1)](https://onco.cc/trials/nct05118789/), [Neladalkib (NVL-655) for TKI-naive Patients With Advanced ALK-Positive NSCLC](https://onco.cc/trials/nct06765109/)

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JSON: https://onco.cc/api/v1/entities/nvl.json