# NXF1

Source: https://onco.cc/targets/nxf1/  
OnCo record `nxf1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

NXF1 (Nuclear RNA export factor 1) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Chronic lymphocytic leukaemia.

## Summary

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export.

IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Chronic Lymphocytic Leukaemia/Small Lymphocytic Lymphoma.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: nuclear RNA export factor 1; Nuclear RNA export factor 1; Mex67; DKFZp667O0311
- Tags: cancer-genes-wave
- Symbol: NXF1
- Class: tumor-suppressor
- Biology: Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export. Location: Nucleus; Nucleus, nucleoplasm; Nucleus speckle; Nucleus, nuclear pore complex (UniProt). Locus 11q12.3 (HGNC).
- Where found: Chronic lymphocytic leukaemia: IntOGen driver in 2 cohorts (CLLSLL)

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier "cohort-driver" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8071: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8071
- UniProt Q9UBU9: https://www.uniprot.org/uniprotkb/Q9UBU9/entry
- NCBI Gene 10482: https://www.ncbi.nlm.nih.gov/gene/10482
- Ensembl ENSG00000162231: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000162231

## Connected records

- collections: [IntOGen](https://onco.cc/collections/intogen/)
- cancers: [Chronic lymphocytic leukaemia](https://onco.cc/cancers/cll/)

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JSON: https://onco.cc/api/v1/entities/nxf1.json