# OGG1

Source: https://onco.cc/targets/ogg1/  
OnCo record `ogg1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

OGG1 (N-glycosylase/DNA lyase) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.

## Summary

DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Open Targets scores its association with cancer at 0.66 (direct and indirect evidence; datatypes genetic literature 0.30, affected pathway 0.89, literature 0.98, genetic association 0.01, somatic mutation 0.55, animal model 0.74).

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: 8-oxoguanine DNA glycosylase; N-glycosylase/DNA lyase; HOGG1; OGH1
- Tags: cancer-genes-wave
- Symbol: OGG1
- Class: enzyme
- Biology: DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. Location: Nucleus, nucleoplasm; Nucleus speckle; Nucleus matrix; Nucleus (UniProt). Locus 3p25.3 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt keyword "DNA repair". Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8125: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8125
- UniProt O15527: https://www.uniprot.org/uniprotkb/O15527/entry
- NCBI Gene 4968: https://www.ncbi.nlm.nih.gov/gene/4968
- Ensembl ENSG00000114026: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000114026

## Connected records

- collections: [Open Targets Platform](https://onco.cc/collections/open-targets/)

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JSON: https://onco.cc/api/v1/entities/ogg1.json