# ONK Therapeutics

Source: https://onco.cc/companies/onk-therapeutics/  
OnCo record `onk-therapeutics` (Company). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ONK Therapeutics, based in Galway, Ireland, is developing off-the-shelf natural killer cell therapies that are gene-edited and given two ways to kill cancer cells at once. It is a private, preclinical-stage company spun out of University of Galway research.

## Summary

ONK Therapeutics is a privately held Irish company founded in 2015 on the NK cell and apoptosis research of Prof Michael O'Dwyer and collaborators at the University of Galway. It is developing next-generation off-the-shelf, optimally engineered natural killer (NK) cell therapies for haematological malignancies and solid tumours. Its platform combines a chimeric antigen receptor against a tumour antigen with a TRAIL variant that engages the death receptor pathway (DR4 or DR5), a dual-targeted design intended to improve efficacy and reduce antigen escape; the company also holds a European patent on CISH knockout in NK cells. In December 2023 ONK announced a research partnership with NAYA Biosciences to combine its NK cells with FLEX-NK bispecific antibodies. No clinical trial or financing round was described on the fetched pages.

## Fields

- Kind: Company
- Last checked: 2026-09-10
- HQ: Galway
- Type: cell-therapy
- Website: https://www.onktherapeutics.com/

## Notes

- No funding round sourced (company is private and Irish, no SEC filings). Most recent news item on the site is dated December 2023, so current activity level is uncertain.

## Sources

- Official website: https://www.onktherapeutics.com/
- About ONK: https://www.onktherapeutics.com/about/
- News: https://www.onktherapeutics.com/news/

## Connected records

- fronts: [Cell Therapy](https://onco.cc/fronts/cell-therapy/)
- technologies: [Allogeneic (off-the-shelf) cell therapy](https://onco.cc/technologies/allogeneic-cell-therapy/), [CAR-NK & CAR-macrophage](https://onco.cc/technologies/car-nk-macrophage/)

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