# ORC1

Source: https://onco.cc/targets/orc1/  
OnCo record `orc1` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

ORC1 (Origin recognition complex subunit 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Triple-negative breast cancer.

## Summary

Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: origin recognition complex subunit 1; Origin recognition complex subunit 1; HSORC1; PARC1; ORC1L
- Tags: cancer-genes-wave
- Symbol: ORC1
- Class: other
- Biology: Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Location: Nucleus (UniProt). Locus 1p32.3 (HGNC).
- Where found: Triple-negative breast cancer: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:8487: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8487
- UniProt Q13415: https://www.uniprot.org/uniprotkb/Q13415/entry
- NCBI Gene 4998: https://www.ncbi.nlm.nih.gov/gene/4998
- Ensembl ENSG00000085840: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000085840

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Triple-negative breast cancer (TNBC)](https://onco.cc/cancers/tnbc/)

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JSON: https://onco.cc/api/v1/entities/orc1.json