# Orlucent System

Source: https://onco.cc/drugs/orlucent-system/  
OnCo record `orlucent-system` (Device or software). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

The Orlucent System is a handheld skin imager from Orlucent that uses a fluorescent agent to judge whether a mole may be becoming melanoma. It is in clinical trials and for research use only in the United States.

## Summary

The Orlucent System from Orlucent is a handheld fluorescent molecular imaging system that assesses the likelihood of a mole's transition to melanoma; the company states it is in clinical trials and for research use only in the United States. Its imaging agent ORL1 is the subject of NCI SBIR grant 1R44CA306680-01A1, which funds manufacturing controls to current Good Manufacturing Practice and reports, from preliminary studies, 100 per cent sensitivity and 95.7 per cent specificity in distinguishing melanomas from non-melanomas.

## Fields

- Kind: Device or software
- Last checked: 2026-11-04
- Also known as: ORL1; Orlucent Skin Fluorescent Imaging System
- Tags: pipeline
- Modality: Handheld fluorescent molecular skin imaging system with topical imaging agent (device)
- Mechanism: A fluorescent imaging agent, ORL1, is applied to a skin lesion and a handheld imager reads its signal to assess molecular changes linked to melanoma, as described by the company and its NCI award.

## Sources

- Orlucent: https://orlucent.com/
- NIH RePORTER: award 1R44CA306680-01A1: https://reporter.nih.gov/project-details/11410547

## Connected records

- fronts: [Early Detection & Screening](https://onco.cc/fronts/early-detection/), [Imaging](https://onco.cc/fronts/imaging/)
- technologies: [Optical & fluorescence imaging](https://onco.cc/technologies/optical-imaging/)
- companies: [Orlucent](https://onco.cc/companies/orlucent/)

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JSON: https://onco.cc/api/v1/entities/orlucent-system.json