# OSBPL10

Source: https://onco.cc/targets/osbpl10/  
OnCo record `osbpl10` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

OSBPL10 (Oxysterol-binding protein-related protein 10) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Diffuse large B-cell lymphoma.

## Summary

Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: oxysterol binding protein like 10; Oxysterol-binding protein-related protein 10
- Tags: cancer-genes-wave
- Symbol: OSBPL10
- Class: other
- Biology: Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P. Plays a role in negative regulation of lipid biosynthesis. Interacts with OSBPL9 to function as lipid transfer proteins. Together they form a heterodimer that localises at the ER-trans-Golgi membrane contact sites, and exchanges phosphatidylserine (1,2-diacyl-sn-glycero-3-phospho-L-serine, PS) for phosphatidylinositol-4-phosphate (1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate), PI(4)P) between the two organelles, a step that is critical for sphingomyelin synthesis in the Golgi complex. Negatively regulates APOB secretion from hepatocytes. Location: Cytoplasm, cytoskeleton; Late endosome membrane; Golgi apparatus, trans-Golgi network membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane (UniProt). Locus 3p23 (HGNC).
- Where found: Diffuse large B-cell lymphoma: CIViC evidence names this disease

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.

## Sources

- HGNC HGNC:16395: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:16395
- UniProt Q9BXB5: https://www.uniprot.org/uniprotkb/Q9BXB5/entry
- NCBI Gene 114884: https://www.ncbi.nlm.nih.gov/gene/114884
- Ensembl ENSG00000144645: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144645

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)
- cancers: [Diffuse large B-cell lymphoma](https://onco.cc/cancers/dlbcl/)

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JSON: https://onco.cc/api/v1/entities/osbpl10.json