# OVOL2

Source: https://onco.cc/targets/ovol2/  
OnCo record `ovol2` (Target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

OVOL2 (Transcription factor Ovo-like 2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.

## Summary

Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation.

CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cisplatin.

## Fields

- Kind: Target
- Last checked: 2026-09-23
- Also known as: ovo like zinc finger 2; Transcription factor Ovo-like 2; bA504H3.3; HOVO2; ZNF339; CHED1
- Tags: cancer-genes-wave
- Symbol: OVOL2
- Class: transcription
- Biology: Zinc-finger transcription repressor factor. Plays a critical role in maintaining the identity of epithelial lineages by suppressing epithelial-to mesenchymal transition (EMT) mainly through the repression of ZEB1, an EMT inducer. Positively regulates neuronal differentiation. Suppresses cell cycling and terminal differentiation of keratinocytes by directly repressing MYC and NOTCH1. Important for the correct development of primordial germ cells in embryos. Plays dual functions in thermogenesis and adipogenesis to maintain energy balance. Location: Nucleus (UniProt). Locus 20p11.23 (HGNC).

## Notes

- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC lists 1 therapies; CIViC holds 1 clinical evidence items on its variants. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Glandular Pattern Ovarian Yolk Sac Tumour.

## Sources

- HGNC HGNC:15804: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15804
- UniProt Q9BRP0: https://www.uniprot.org/uniprotkb/Q9BRP0/entry
- NCBI Gene 58495: https://www.ncbi.nlm.nih.gov/gene/58495
- Ensembl ENSG00000125850: https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000125850

## Connected records

- collections: [CIViC](https://onco.cc/collections/civic/)

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JSON: https://onco.cc/api/v1/entities/ovol2.json