# The 2023 Bethesda System for Reporting Thyroid Cytopathology

Source: https://onco.cc/key-papers/paper-ali-thyroid/  
OnCo record `paper-ali-thyroid` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one technology page and one term page, indexed on Europe PMC as PubMed record 37427847 and published in Thyroid; the citing pages link this DOI, which is how the record was matched.

## Summary

Since the publication of the first edition in 2010, The Bethesda System for Reporting Thyroid Cytopathology has allowed cytopathologists to use a standardized, category-based reporting system for thyroid fine needle aspirations. The third edition builds on the success of the 2 earlier editions and offers several key updates. The most important is the assignment of a single name for each of the 6 diagnostic categories: (i) nondiagnostic; (ii) benign; (iii) atypia of undetermined significance; (iv) follicular neoplasm; (v) suspicious for malignancy; and (vi) malignant. Each of the categories has an implied risk of malignancy (ROM), which has been updated and refined based on data reported after the second edition. The third edition offers an average ROM for each category, in addition to the expected range of cancer risk. The atypia of undetermined significance subcategorization is simplified into 2 subgroups based on the implied ROM and molecular profiling. A discussion of pediatric thyroid disease has been added, and pediatric ROMs and management algorithms are discussed in the relevant sections. Nomenclature has been updated to align with the 2022 World Health Organization Classification of Thyroid Neoplasms. Two new chapters have been added: one that addresses the significant and expanded use of molecular and ancillary testing in thyroid cytopathology, and another that summarizes clinical perspectives and imaging findings in thyroid disease.

Indexed on Europe PMC as PubMed record 37427847 (DOI 10.1089/thy.2023.0141). Matched by DOI alone: one technology page and one term page cite this DOI among their external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Thyroid
- Year: 2023
- DOI: 10.1089/thy.2023.0141
- Authors: Ali SZ, Baloch ZW, Cochand-Priollet B, et al.
- What it means: One technology page and one term page on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Thyroid 2023: https://doi.org/10.1089/thy.2023.0141
- PubMed: https://pubmed.ncbi.nlm.nih.gov/37427847/
- Europe PMC: https://europepmc.org/article/MED/37427847

## Connected records

- technologies: [Thyroid nodule FNA, Bethesda cytology & molecular classifiers](https://onco.cc/technologies/thyroid-fna-molecular/)
- terms: [Bethesda category (thyroid cytology)](https://onco.cc/terms/bethesda-category/)

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