# Prospective multi-institutional study of adjuvant radiotherapy after resection of borderline and malignant phyllodes tumours

Source: https://onco.cc/key-papers/paper-barth-phyllodes-adjuvant-radiotherapy-ann-surg-oncol-2009/  
OnCo record `paper-barth-phyllodes-adjuvant-radiotherapy-ann-surg-oncol-2009` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

In a prospective study, no woman whose borderline or malignant phyllodes tumour was excised with clear margins and then given radiotherapy had a local recurrence, supporting radiotherapy after breast-conserving surgery for these tumours.

## Summary

Prospective study of 46 women with borderline or malignant phyllodes tumours treated with margin-negative breast-conserving resection followed by adjuvant radiotherapy.

With a median follow-up of 56 months there were no local recurrences, compared with historical local recurrence rates of 15 to 30 percent after surgery alone, though distant metastases occurred in a small number of malignant cases.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Annals of surgical oncology
- Year: 2009
- DOI: 10.1245/s10434-009-0489-2
- Authors: Barth RJ, Wells WA, Mitchell SE, et al.
- Findings: Local recurrence 0 percent at a median of 56 months after resection plus radiotherapy.
- What it means: Adjuvant radiotherapy is considered after breast conservation for borderline and malignant phyllodes tumours; it does not address the risk of distant spread.
- Caveats: Small, non-randomised study with a historical comparison.

## Sources

- Ann Surg Oncol 2009: https://doi.org/10.1245/s10434-009-0489-2
- PubMed: https://pubmed.ncbi.nlm.nih.gov/19424757/

## Connected records

- cancers: [Phyllodes tumour of the breast](https://onco.cc/cancers/phyllodes-tumour/)
- journals: [Annals of surgical oncology](https://onco.cc/journals/annals-of-surgical-oncology/)

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