# Drug development: Raise standards for preclinical cancer research

Source: https://onco.cc/key-papers/paper-begley-nature/  
OnCo record `paper-begley-nature` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by two bottleneck pages, indexed on Europe PMC as PubMed record 22460880 and published in Nature; the citing pages link this DOI, which is how the record was matched.

## Summary

Europe PMC indexes no abstract for this record; the title is the only text available.

Indexed on Europe PMC as PubMed record 22460880 (DOI 10.1038/483531a). Matched by DOI alone: two bottleneck pages cite this DOI among their external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature
- Year: 2012
- DOI: 10.1038/483531a
- Authors: Begley CG, Ellis LM
- What it means: Two bottleneck pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nature 2012: https://doi.org/10.1038/483531a
- PubMed: https://pubmed.ncbi.nlm.nih.gov/22460880/
- Europe PMC: https://europepmc.org/article/MED/22460880

## Connected records

- bottlenecks: [Lab models that fail to predict what happens in patients](https://onco.cc/bottlenecks/b-preclinical-models/), [Preclinical results do not reproduce](https://onco.cc/bottlenecks/b-reproducibility/)
- journals: [Nature](https://onco.cc/journals/nature/)

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