# BMT CTN 0803/AMC 071: autologous haematopoietic cell transplantation for HIV-related lymphoma

Source: https://onco.cc/key-papers/paper-bmt-ctn-0803-autologous-transplant-hiv-lymphoma-alvarnas-blood-2016/  
OnCo record `paper-bmt-ctn-0803-autologous-transplant-hiv-lymphoma-alvarnas-blood-2016` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

People with HIV whose lymphoma had relapsed did as well after high-dose chemotherapy and a stem cell transplant as matched HIV-negative patients, with 87 percent alive at one year.

## Summary

Single-arm phase 2 trial of the Blood and Marrow Transplant Clinical Trials Network and AIDS Malignancy Consortium: 43 HIV-infected patients with chemotherapy-sensitive relapsed or persistent aggressive B-cell or Hodgkin lymphoma were enrolled and 40 underwent autologous transplant after BEAM conditioning with consistent peri-transplant antiretroviral management.

At a median follow-up of 24.8 months one- and two-year overall survival were 87.3 and 82 percent, two-year progression-free survival 79.8 percent and one-year transplant-related mortality 5.2 percent; neutrophil and platelet recovery took 11 and 18 days; outcomes did not differ from 151 matched registry controls.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Journal: Blood
- Year: 2016
- DOI: 10.1182/blood-2015-08-664706
- Authors: Alvarnas JC, Le Rademacher J, Wang Y, et al.
- Findings: One-year overall survival 87.3 percent (95% CI 72.1 to 94.5) and two-year 82 percent (65.9 to 91).; Two-year progression-free survival 79.8 percent; one-year transplant-related mortality 5.2 percent.; No significant difference from 151 matched HIV-negative controls.
- What it means: HIV infection is not a reason to withhold autologous transplant from patients with relapsed lymphoma who meet standard transplant criteria.
- Caveats: Small single-arm study in patients with controlled HIV and chemotherapy-sensitive disease.

## Sources

- Blood 2016: https://doi.org/10.1182/blood-2015-08-664706
- PubMed: https://pubmed.ncbi.nlm.nih.gov/27297790/

## Connected records

- cancers: [HIV-associated (AIDS-related) lymphomas](https://onco.cc/cancers/hiv-associated-lymphoma/)
- trials: [BMT CTN 0803](https://onco.cc/trials/bmt-ctn-0803/)
- journals: [Blood](https://onco.cc/journals/blood/)

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