# Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell

Source: https://onco.cc/key-papers/paper-bonnet-nat-med/  
OnCo record `paper-bonnet-nat-med` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one term page, indexed on Europe PMC as PubMed record 9212098 and published in Nature Medicine; the citing page links this DOI, which is how the record was matched.

## Summary

On the subject of acute myeloid leukemia (AML), there is little consensus about the target cell within the hematopoietic stem cell hierarchy that is susceptible to leukemic transformation, or about the mechanism that underlies the phenotypic, genotypic and clinical heterogeneity. Here we demonstrate that the cell capable of initiating human AML in non-obese diabetic mice with severe combined immunodeficiency disease (NOD/SCID mice) - termed the SCID leukemia-initiating cell, or SL-IC - possesses the differentiative and proliferative capacities and the potential for self-renewal expected of a leukemic stem cell. The SL-ICs from all subtypes of AML analyzed, regardless of the heterogeneity in maturation characteristics of the leukemic blasts, were exclusively CD34++ CD38-, similar to the cell-surface phenotype of normal SCID-repopulating cells, suggesting that normal primitive cells, rather than committed progenitor cells, are the target for leukemic transformation. The SL-ICs were able to differentiate in vivo into leukemic blasts, indicating that the leukemic clone is organized as a hierarchy.

Indexed on Europe PMC as PubMed record 9212098 (DOI 10.1038/nm0797-730). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature Medicine
- Year: 1997
- DOI: 10.1038/nm0797-730
- Authors: Bonnet D, Dick JE
- What it means: One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nat Med 1997: https://doi.org/10.1038/nm0797-730
- PubMed: https://pubmed.ncbi.nlm.nih.gov/9212098/
- Europe PMC: https://europepmc.org/article/MED/9212098

## Connected records

- terms: [Cancer stem cell theory and phenotypic plasticity](https://onco.cc/terms/cancer-stem-cell-theory/)
- journals: [Nature Medicine](https://onco.cc/journals/nature-medicine/)

---
JSON: https://onco.cc/api/v1/entities/paper-bonnet-nat-med.json