# Primary retroperitoneal sarcomas: a multivariate analysis of surgical factors associated with local control

Source: https://onco.cc/key-papers/paper-bonvalot-retroperitoneal-sarcoma-compartmental-jco-2009/  
OnCo record `paper-bonvalot-retroperitoneal-sarcoma-compartmental-jco-2009` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This French multicentre study showed that resecting a retroperitoneal sarcoma together with the adjacent organs, even when not obviously involved, reduced local recurrence more than threefold, establishing the compartmental surgical approach.

## Summary

Retrospective analysis of 382 patients with primary retroperitoneal sarcoma from French Sarcoma Group centres examining surgical technique, margins and outcomes.

Systematic en bloc resection of adjacent organs (compartmental resection) was associated with a 3.29-fold lower risk of abdominal recurrence compared with simple complete resection, without higher mortality, while incomplete resection and high grade predicted recurrence.

## Fields

- Kind: Key paper
- Last checked: 2026-09-17
- Journal: Journal of Clinical Oncology
- Year: 2009
- DOI: 10.1200/JCO.2008.18.0802
- Authors: Bonvalot S, Rivoire M, Castaing M, et al.
- Findings: Abdominal recurrence risk reduced 3.29-fold with compartmental resection.; Postoperative mortality 3 percent.
- What it means: Extended en bloc resection in a sarcoma reference centre is the standard operation for retroperitoneal sarcoma.
- Caveats: Retrospective; extended resection carries morbidity and remains debated for low-grade liposarcoma.

## Sources

- J Clin Oncol 2009: https://doi.org/10.1200/JCO.2008.18.0802
- PubMed: https://pubmed.ncbi.nlm.nih.gov/19047280/

## Connected records

- cancers: [Retroperitoneal sarcoma](https://onco.cc/cancers/retroperitoneal-sarcoma/)
- journals: [Journal of Clinical Oncology](https://onco.cc/journals/jco/)

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