# Transcriptional Addiction in Cancer

Source: https://onco.cc/key-papers/paper-bradner-cell/  
OnCo record `paper-bradner-cell` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one pathway page, indexed on Europe PMC as PubMed record 28187285 and published in Cell; the citing page links this DOI, which is how the record was matched.

## Summary

Cancer arises from genetic alterations that invariably lead to dysregulated transcriptional programs. These dysregulated programs can cause cancer cells to become highly dependent on certain regulators of gene expression. Here, we discuss how transcriptional control is disrupted by genetic alterations in cancer cells, why transcriptional dependencies can develop as a consequence of dysregulated programs, and how these dependencies provide opportunities for novel therapeutic interventions in cancer.

Indexed on Europe PMC as PubMed record 28187285 (DOI 10.1016/j.cell.2016.12.013). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Cell
- Year: 2017
- DOI: 10.1016/j.cell.2016.12.013
- Authors: Bradner JE, Hnisz D, Young RA
- What it means: One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Cell 2017: https://doi.org/10.1016/j.cell.2016.12.013
- PubMed: https://pubmed.ncbi.nlm.nih.gov/28187285/
- Europe PMC: https://europepmc.org/article/MED/28187285

## Connected records

- pathways: [Transcriptional machinery & addiction](https://onco.cc/pathways/transcription-addiction/)
- journals: [Cell](https://onco.cc/journals/cell/)

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