# Ancestral gene regulatory networks drive cancer

Source: https://onco.cc/key-papers/paper-bussey-proc-natl-acad-sci-u-s-a/  
OnCo record `paper-bussey-proc-natl-acad-sci-u-s-a` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one term page, indexed on Europe PMC as PubMed record 28584134 and published in Proceedings of the National Academy of Sciences; the citing page links this DOI, which is how the record was matched.

## Summary

Europe PMC indexes no abstract for this record; the title is the only text available.

Indexed on Europe PMC as PubMed record 28584134 (DOI 10.1073/pnas.1706990114). Matched by DOI alone: one term page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Proceedings of the National Academy of Sciences
- Year: 2017
- DOI: 10.1073/pnas.1706990114
- Authors: Bussey KJ, Cisneros LH, Lineweaver CH, et al.
- What it means: One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Proc Natl Acad Sci U S A 2017: https://doi.org/10.1073/pnas.1706990114
- PubMed: https://pubmed.ncbi.nlm.nih.gov/28584134/
- Europe PMC: https://europepmc.org/article/MED/28584134

## Connected records

- terms: [Atavistic theory: cancer as a reversion to an ancient programme](https://onco.cc/terms/atavistic-theory-of-cancer/)
- journals: [Proceedings of the National Academy of Sciences](https://onco.cc/journals/pnas/)

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