# Translational research: crossing the valley of death

Source: https://onco.cc/key-papers/paper-butler-nature/  
OnCo record `paper-butler-nature` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one bottleneck page and twelve idea pages, indexed on Europe PMC as PubMed record 18548043 and published in Nature; the citing pages link this DOI, which is how the record was matched.

## Summary

Europe PMC indexes no abstract for this record; the title is the only text available.

Indexed on Europe PMC as PubMed record 18548043 (DOI 10.1038/453840a). Matched by DOI alone: one bottleneck page and twelve idea pages cite this DOI among their external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature
- Year: 2008
- DOI: 10.1038/453840a
- Authors: Butler D
- What it means: One bottleneck page and twelve idea pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nature 2008: https://doi.org/10.1038/453840a
- PubMed: https://pubmed.ncbi.nlm.nih.gov/18548043/
- Europe PMC: https://europepmc.org/article/MED/18548043

## Connected records

- bottlenecks: [The valley of death between lab and product](https://onco.cc/bottlenecks/b-translational-valley/)
- ideas: [A diversified royalty pool that finances academic phase 1 trials across fifty assets](https://onco.cc/ideas/idea-fund-royalty-pool-academic-assets/), [A fund for prospective validation of academic biomarkers and companion diagnostics](https://onco.cc/ideas/idea-fund-biomarker-validation-fund/), [A global first-in-human network for academic cancer trials with single ethics review](https://onco.cc/ideas/idea-fund-global-academic-phase-one-network/), [A national non-profit contract research organisation for academic oncology trials](https://onco.cc/ideas/idea-fund-public-nonprofit-cro/), [A phase 0 fund to test academic compounds in humans with microdoses and imaging](https://onco.cc/ideas/idea-fund-phase-zero-fund/), [A public indemnity pool so universities can sponsor first-in-human cancer trials](https://onco.cc/ideas/idea-fund-academic-sponsor-indemnity-pool/), [A public-benefit phase 1 factory that takes academic discoveries into first-in-human trials](https://onco.cc/ideas/idea-moon-public-phase1-factory/), [A translation fund for academic surgical devices and radiotherapy technology](https://onco.cc/ideas/idea-fund-device-and-technique-translation-fund/), [A university cyclotron network with shared regulatory files for new tracers](https://onco.cc/ideas/idea-fund-academic-radiopharma-pipeline/), [Hospital-exemption cell therapies at scale, backed by a shared registry](https://onco.cc/ideas/idea-fund-hospital-exemption-registry/), [Hospital-funded protected time for clinician-scientists, repaid by trial revenue](https://onco.cc/ideas/idea-fund-protected-time-physician-scientists/), [Two-year translational fellowships that pay scientists to develop their own discovery](https://onco.cc/ideas/idea-fund-translational-fellowships/)
- journals: [Nature](https://onco.cc/journals/nature/)

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