# MicroRNA signatures in human cancers

Source: https://onco.cc/key-papers/paper-calin-nat-rev-cancer/  
OnCo record `paper-calin-nat-rev-cancer` (Key paper). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

Paper cited by one pathway page, indexed on Europe PMC as PubMed record 17060945 and published in Nature Reviews Cancer; the citing page links this DOI, which is how the record was matched.

## Summary

MicroRNA (miRNA) alterations are involved in the initiation and progression of human cancer. The causes of the widespread differential expression of miRNA genes in malignant compared with normal cells can be explained by the location of these genes in cancer-associated genomic regions, by epigenetic mechanisms and by alterations in the miRNA processing machinery. MiRNA-expression profiling of human tumours has identified signatures associated with diagnosis, staging, progression, prognosis and response to treatment. In addition, profiling has been exploited to identify miRNA genes that might represent downstream targets of activated oncogenic pathways, or that target protein-coding genes involved in cancer.

Indexed on Europe PMC as PubMed record 17060945 (DOI 10.1038/nrc1997). Matched by DOI alone: one pathway page cites this DOI among its external links (the pages are listed under Related), and this page was written so that the citation resolves inside OnCo. No figure has been checked by an editor.

## Fields

- Kind: Key paper
- Last checked: 2026-09-22
- Tags: europepmc-ingest
- Journal: Nature Reviews Cancer
- Year: 2006
- DOI: 10.1038/nrc1997
- Authors: Calin GA, Croce CM
- What it means: One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
- Caveats: Matched to the citing OnCo records by DOI alone; the summary reproduces the Europe PMC abstract and no figure has been verified against the full paper.

## Sources

- Nat Rev Cancer 2006: https://doi.org/10.1038/nrc1997
- PubMed: https://pubmed.ncbi.nlm.nih.gov/17060945/
- Europe PMC: https://europepmc.org/article/MED/17060945

## Connected records

- pathways: [MicroRNAs in cancer](https://onco.cc/pathways/micrornas-in-cancer/)
- journals: [Nature Reviews Cancer](https://onco.cc/journals/nature-reviews-cancer/)

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